Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.

@article{Dave2005IschemicPA,
  title={Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.},
  author={Kunjan R Dave and Christian Lange-Asschenfeldt and Ami P. Raval and Ricardo Prado and Raul Busto and Isabel Saul and M. A. P{\'e}rez-pinz{\'o}n},
  journal={Journal of neuroscience research},
  year={2005},
  volume={82 5},
  pages={
          665-73
        }
}
Excitotoxicity is recognized to play a major role in cerebral ischemia-induced cell death. The main goal of the present study was to define whether our model of ischemic preconditioning (IPC) promotes a shift from excitatory to inhibitory neurotransmission during the test ischemia to diminish metabolic demand during the reperfusion phase. We also determined whether gamma-aminobutyric acid (GABA) played a role in IPC-induced neuroprotection. Ten minutes of cerebral ischemia was produced by… CONTINUE READING

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