Ischemic injury in the cat small intestine: role of superoxide radicals.

@article{Parks1982IschemicII,
  title={Ischemic injury in the cat small intestine: role of superoxide radicals.},
  author={Dale A. Parks and Gregory B. Bulkley and Dr. D. Neil Granger and Scott Hamilton and J M Mccord},
  journal={Gastroenterology},
  year={1982},
  volume={82 1},
  pages={9-15}
}
Hemorrhagic lesions in the small intestinal mucosa have been demonstrated in humans and experimental animals following hemorrhagic shock and intestinal ischemia. In order to define the role of superoxide radicals and xanthine oxidase in the pathogenesis of the mucosal lesions, we compared the microscopic mucosal changes produced by 3 h of regional hypotension (intestinal arterial pressure = 30 mmHg) in untreated cats and cats pretreated with either superoxide dismutase or allopurinol. In the… CONTINUE READING