Ischemic and reperfusion injury of cyanotic myocardium in chronic hypoxic rat model: changes in cyanotic myocardial antioxidant system.

@article{Nakanishi1997IschemicAR,
  title={Ischemic and reperfusion injury of cyanotic myocardium in chronic hypoxic rat model: changes in cyanotic myocardial antioxidant system.},
  author={Katsuyuki Nakanishi and Masahiro Inoue and Eika Sugawara and Shunji Sano},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1997},
  volume={114 6},
  pages={1088-96}
}
OBJECTIVE The objective was to evaluate the effect of left ventricular function on cyanotic myocardium after ischemia-reperfusion and to determine the effect of cyanosis on the myocardial antioxidant system. METHODS Cyanotic hearts (cyanotic group) were obtained from rats housed in a hypoxic chamber (10% oxygen) for 2 weeks and control hearts (control group) from rats maintained in ambient air. Isolated, crystalloid perfused working hearts were subjected to 15 minutes of global normothermic… CONTINUE READING

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