Ischemic Stroke in Mice and Rats

@article{Durukan2009IschemicSI,
  title={Ischemic Stroke in Mice and Rats},
  author={Aysan Durukan and Turgut Tatlisumak},
  journal={Methods in molecular biology},
  year={2009},
  volume={573},
  pages={95-114}
}
Ischemic stroke occurs most often in the territory of the middle cerebral artery (MCA) in humans. Since its description in rats more than two decades ago, the minimally invasive intraluminal suture occlusion of MCA is an increasingly used model of stroke in both rats and mice due to its ease of inducing ischemia and achieving reperfusion under well-controlled conditions. This method can be used under the guidance of laser-Doppler flowmetry to ascertain the magnitude of occlusion or reperfusion… CONTINUE READING

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