Ischemic Neuroprotection by TRPV1 Receptor-Induced Hypothermia

@article{Muzzi2012IschemicNB,
  title={Ischemic Neuroprotection by TRPV1 Receptor-Induced Hypothermia},
  author={Mirko Muzzi and Roberta de Felici and Leonardo Cavone and Elisabetta Gerace and Alberto Minassi and Giovanni Appendino and Flavio Moroni and Alberto Chiarugi},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={2012},
  volume={32},
  pages={978 - 982}
}
Although treatment of stroke patients with mild hypothermia is a promising therapeutic approach, chemicals inducing prompt and safe reduction of body temperature are an unmet need. We measured the effects of the transient receptor potential vanilloid-1 (TRPV1) agonist rinvanil on thermoregulation and ischemic brain injury in mice. Intraperitoneal or intracerebroventricular injection of rinvanil induces mild hypothermia that is prevented by the receptor antagonist capsazepine. Both intraischemic… CONTINUE READING

Citations

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