Ischemia-reperfusion injury: processes in pathogenetic networks: a review.

  title={Ischemia-reperfusion injury: processes in pathogenetic networks: a review.},
  author={Herbert de Groot and Ursula Rauen},
  journal={Transplantation proceedings},
  volume={39 2},
Ischemia-reperfusion injury is a complex phenomenon involving not only intracellular injury processes but also an injurious inflammatory response. Both the intracellular injury processes and the injurious events of the inflammatory response are interconnected in pathogenetic networks. Anoxic cell injury predominates in the ischemic phase. The decreased mitochondrial ATP generation impairs cellular ion homeostasis with activation of hydrolases and loss of selective permeability of cell membranes… CONTINUE READING
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