Ischemia-reperfusion-induced muscle damage. Protective effect of corticosteroids and antioxidants in rabbits.

@article{Bushell1996IschemiareperfusioninducedMD,
  title={Ischemia-reperfusion-induced muscle damage. Protective effect of corticosteroids and antioxidants in rabbits.},
  author={Alison J Bushell and Leslie Klenerman and Huw M. L. Davies and I. O. Grierson and Malcolm J. Jackson},
  journal={Acta orthopaedica Scandinavica},
  year={1996},
  volume={67 4},
  pages={393-8}
}
We examined the potential protective effect of pretreatment with corticosteroids or antioxidants (ascorbic acid or allopurinol) in rabbits with reperfusion-induced damage to skeletal muscle after ischemia. 4 hours of limb ischemia induced by a pneumatic tourniquet, followed by reperfusion for 1 hour, caused a considerable amount of ultrastructural damage to… CONTINUE READING