Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition.

@article{French2006IschemiareperfusioninducedCA,
  title={Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition.},
  author={Joel P. French and John C Quindry and Darin J. Falk and Jessica L Staib and Youngil Lee and Kevin Ka Wan Wang and Scott K. Powers},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 1},
  pages={H128-36}
}
The Ca2+-activated protease calpain has been shown to play a deleterious role in the heart during ischemia-reperfusion (I/R). We tested the hypothesis that exercise training would minimize I/R-induced calpain activation and provide cardioprotection against I/R-induced injury. Hearts from adult male rats were isolated in a working heart preparation, and myocardial injury was induced with 25 min of global ischemia followed by 45 min of reperfusion. In sedentary control rats, I/R significantly… CONTINUE READING