Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: Their possible correlation in astrocytes

@article{Hwang2006IschemiarelatedCO,
  title={Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: Their possible correlation in astrocytes},
  author={In Koo Hwang and Ki-Yeon Yoo and Dae Won Kim and Bong-Hee Lee and Tae-Cheon Kang and Soo-Young Choi and Byoung Hee Han and Jong S Kim and Moo-Ho Won},
  journal={Brain Research},
  year={2006},
  volume={1072},
  pages={215-223}
}
In the present study, we observed the changes of endogenous expression of glial-cell-line-derived neurotrophic factor (GDNF) and phosphatidylinositol 3-kinase (PI-3 kinase) in the gerbil hippocampus after transient forebrain ischemia and investigated the correlation between GDNF and PI-3 kinase in the ischemic hippocampus. In the sham-operated group, GDNF and PI-3 kinase immunoreactivity was not found in any cells in the hippocampal CA1 region. GDNF, not PI-3 kinase, immunoreactivity was… Expand
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