Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain.

@article{Daoud2002IschemiaIA,
  title={Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain.},
  author={Rosette Daoud and Guenter Mies and Agata Smialowska and Laszlo Ol{\'a}h and K. A. Hossmann and Stefan Stamm},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 14},
  pages={5889-99}
}
Alternative splice-site selection is regulated by the relative concentration of individual members of the serine-arginine family of proteins and heterogeneous nuclear ribonucleoproteins. Most of these proteins accumulate predominantly in the nucleus, and a subset of them shuttles continuously between nucleus and cytosol. We demonstrate that in primary neuronal cultures, a rise in intracellular calcium concentration induced by thapsigargin leads to a translocation of the splicing regulatory… CONTINUE READING