Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells.

  title={Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells.},
  author={M C Kuo and D Patschan and Susann A Patschan and Leona Cohen-Gould and Hyeong-Cheon Park and Jei Ni and Francesco Addabbo and Michael S. Goligorsky},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={19 12},
Recruitment of various stem and progenitor cells is crucial for the regeneration of an injured organ. Levels of uric acid, one of the prototypical "alarm signals," surge after ischemia-reperfusion injury. Exogenous uric acid rapidly mobilizes endothelial progenitor cells and hematopoietic stem cells and protects the kidney from ischemia. The relatively fast responses to uric acid suggest that preformed second messengers may be released from a storage pool. Here, it is reported that monosodium… CONTINUE READING
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