Ischemia-induced depolarizations and associated hemodynamic responses in incomplete global forebrain ischemia in rats.

@article{Bere2014IschemiainducedDA,
  title={Ischemia-induced depolarizations and associated hemodynamic responses in incomplete global forebrain ischemia in rats.},
  author={Zs{\'o}fia Bere and Tihomir P. Obrenovitch and Ferenc Bari and Eszter Farkas},
  journal={Neuroscience},
  year={2014},
  volume={260},
  pages={217-26}
}
Spontaneous depolarizations around the core are a consistent feature of focal cerebral ischemia, but the associated regional hemodynamic changes are heterogeneous. We determined how the features of depolarizations relate to subsequent cerebral blood flow (CBF) changes in global forebrain ischemia. Forebrain ischemia was produced in halothane-anesthetized rats (n=13) by common carotid artery occlusion and hypovolemic hypotension. Mean arterial blood pressure (MABP) was monitored via a femoral… CONTINUE READING

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