Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity.

Abstract

Although ischemia is associated with disruption of cadherin-mediated adhesion in renal cell lines, the impact of decreased cadherin function on the transcriptional activity of beta-catenin remains poorly defined. In these studies, we used a simulated ischemia model in normal rat kidney (NRK) cells to disrupt cadherin function. Cell viability; cadherin… (More)

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