Ischemia-driven angiogenesis.

Abstract

New blood vessels usually develop in places where they are most needed. A prime example of neovascularization representing a positive feedback response to insufficient perfusion is the development of collateral blood vessels in the ischemic myocardium and leg. The recent discoveries of hypoxia-inducible transcription and angiogenic factors have provided… (More)
DOI: 10.1016/S1050-1738(97)00091-1

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