Ischemia contributes to adverse effects of cocaine on brain development: suppression of ornithine decarboxylase activity in neonatal rat.

@article{Koegler1991IschemiaCT,
  title={Ischemia contributes to adverse effects of cocaine on brain development: suppression of ornithine decarboxylase activity in neonatal rat.},
  author={S M Koegler and Frederic J. Seidler and John R. Spencer and Theodore A. Slotkin},
  journal={Brain research bulletin},
  year={1991},
  volume={27 6},
  pages={829-34}
}
Exposure to cocaine during development has been shown to cause structural and functional alterations in the nervous system. In the current study, the mechanisms underlying these effects were examined in neonatal rats through measurement of ornithine decarboxylase activity, a key regulatory enzyme in the control of neural cell differentiation. Animals were given cocaine (30 mg/kg SC) and ornithine decarboxylase measured 1 and 4 h later in midbrain + brainstem, cerebral cortex and cerebellum… CONTINUE READING