Ischemia activates actin depolymerizing factor: role in proximal tubule microvillar actin alterations.

@article{Schwartz1999IschemiaAA,
  title={Ischemia activates actin depolymerizing factor: role in proximal tubule microvillar actin alterations.},
  author={Noa Schwartz and Melanie Hosford and Ruben M. Sandoval and Mark C. Wagner and Simon J. Atkinson and J W Bamburg and Bruce A Molitoris},
  journal={The American journal of physiology},
  year={1999},
  volume={276 4},
  pages={
          F544-51
        }
}
Apical membrane of renal proximal tubule cells is extremely sensitive to ischemia, with structural alterations occurring within 5 min. These changes are felt secondary to actin cytoskeletal disruption, yet the mechanism responsible is unknown. Actin depolymerizing factor (ADF), a 19-kDa actin-binding protein, has recently been shown to play an important role in regulation of actin filament dynamics. Because ADF is known to mediate pH-dependent F-actin binding, depolymerization, and severing… CONTINUE READING

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