Ischemia activates actin depolymerizing factor: role in proximal tubule microvillar actin alterations.

@article{Schwartz1999IschemiaAA,
  title={Ischemia activates actin depolymerizing factor: role in proximal tubule microvillar actin alterations.},
  author={Niles Schwartz and Melanie A Hosford and Ruben M. Sandoval and M. C. Wagner and Simon J. Atkinson and James R. Bamburg and Bruce A Molitoris},
  journal={American journal of physiology. Renal physiology},
  year={1999},
  volume={276 4},
  pages={F544-F551}
}
Apical membrane of renal proximal tubule cells is extremely sensitive to ischemia, with structural alterations occurring within 5 min. These changes are felt secondary to actin cytoskeletal disruption, yet the mechanism responsible is unknown. Actin depolymerizing factor (ADF), a 19-kDa actin-binding protein, has recently been shown to play an important role in regulation of actin filament dynamics. Because ADF is known to mediate pH-dependent F-actin binding, depolymerization, and severing… CONTINUE READING