Ischemia-Reperfusion Injury in the Intestines of Newborn Pigs

  title={Ischemia-Reperfusion Injury in the Intestines of Newborn Pigs},
  author={Alfonso Papparella and Frank G Deluca and Calvin E. Oyer and Halit Pinar and Barbara S. Stonestreet},
  journal={Pediatric Research},
Although the pathogenesis of necrotizing enterocolitis remains uncertain, ischemia appears to be an important contributing factor to the development of this disorder. Reperfusion plays a major role in ischemia-related injury, and oxygen free radicals produced during reperfusion most likely contribute to the injury. These oxidants can be generated during prostanoid metabolism, which increases during reperfusion of ischemic gut in adult subjects. The present study was designed to: 1) examine the… CONTINUE READING


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