Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation

  title={Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation},
  author={Raffaele Cursio and Jean Gugenheim},
  booktitle={Journal of transplantation},
Ischemia-reperfusion (I-R) injury after liver transplantation (LT) induces intra- and/or extrahepatic nonanastomotic ischemic-type biliary lesions (ITBLs). Subsequent bile duct stricture is a significant cause of morbidity and even mortality in patients who underwent LT. Although the pathogenesis of ITBLs is multifactorial, there are three main interconnected mechanisms responsible for their formation: cold and warm I-R injury, injury induced by cytotoxic bile salts, and immunological-mediated… CONTINUE READING
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The importance of portal venous blood flow in ischemic-type biliary lesions after liver transplantation

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