Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.

@article{Cheng2010IschaemicPM,
  title={Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.},
  author={Yunhui Cheng and Ping Zhu and Jian Ling Yang and Xiaojun Liu and Shimin Dong and Xiaobin Wang and Bao Chun and Jian Zhuang and Chunxiang Zhang},
  journal={Cardiovascular research},
  year={2010},
  volume={87 3},
  pages={
          431-9
        }
}
AIMS The aims of the present study are to determine the miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and to identify an IP-regulated miRNA, miR-21, in IP-mediated cardiac protection, and the potential cellular and molecular mechanisms involved. METHODS AND RESULTS The miRNA expression signature was investigated in rat hearts. Among the 341 arrayed miRNAs, 40 miRNAs were differentially expressed (21 up and 19 down) in rat hearts with IP, compared with their… CONTINUE READING

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