Ischaemic preconditioning delays ischaemia induced cellular electrical uncoupling in rabbit myocardium by activation of ATP sensitive potassium channels.

@article{Tan1993IschaemicPD,
  title={Ischaemic preconditioning delays ischaemia induced cellular electrical uncoupling in rabbit myocardium by activation of ATP sensitive potassium channels.},
  author={Hanno L. Tan and P Maz{\'o}n and Hein Jan Verberne and M E Sleeswijk and Ruben Coronel and Tobias Opthof and Michiel J. Janse},
  journal={Cardiovascular research},
  year={1993},
  volume={27 4},
  pages={
          644-51
        }
}
OBJECTIVE The aim was to examine whether ischaemic preconditioning delays the onset of cellular electrical uncoupling during ischaemia, and whether the effect of preconditioning is mediated by the activation of ATP sensitive K+ channels (IK-ATP). METHODS Onset of uncoupling, action potential duration (APD80), and conduction velocity were measured in an isolated perfused rabbit papillary muscle. Preconditioning consisted of 10 min occlusion and 10 min reperfusion prior to 40 min sustained… CONTINUE READING
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