Ischaemic heart disease mortality study among workers with occupational exposure to ammonium perfluorooctanoate

  title={Ischaemic heart disease mortality study among workers with occupational exposure to ammonium perfluorooctanoate},
  author={Carine J Sakr and James Morel Symons and Kim H. Kreckmann and Robin C. Leonard},
  journal={Occupational and Environmental Medicine},
  pages={699 - 703}
Objectives: Ammonium perfluorooctanoate (APFO) is a biopersistent surfactant used in the manufacture of several types of fluoropolymers. Based on previous findings of increased serum lipid levels associated with exposure to APFO, we evaluated ischaemic heart disease (IHD) mortality in a cohort of occupationally exposed workers. Methods: Relative risks (RR) were estimated from exposure–response analyses of cumulative exposure measures using proportional hazards regression models. Results: 239… 

Cohort mortality study of workers exposed to perfluorooctanoic acid.

Evidence of positive exposure-response trends for malignant and nonmalignant renal disease is found in a cohort of 5,791 workers exposed to PFOA at a DuPont chemical plant in West Virginia from 1979-2004.

Retrospective exposure assessment of perfluorooctanoic acid serum concentrations at a fluoropolymer manufacturing plant.

Estimates of serum PFOA for the worker cohort were developed for the period of 1950-2004 using linear mixed models to account for repeated measures, along with exposure determinants such as cumulative years worked in potentially exposed jobs to reflect the influence of process changes over calendar time on exposure.


The aim is to determine if PFOA workers with high exposures show excess mortality from any cause, and to study mortality through 2008 of 6027 workers occupationally exposed to high exposures at the Dupont chemical plant.

Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts

Higher PFOA exposure was associated with incident hypercholesterolemia with medication, but not with hypertension or coronary artery disease, and high cholesterol in community and worker cohorts.

Association of increased risk of cardiovascular diseases with higher levels of perfluoroalkylated substances in the serum of adults

A positive relationship between mixed PFAS exposure and total CVD risk was indicated; among the PFASs, perfluorooctane sulfonic acid (PFOS) had the highest posterior inclusion probability and a significant relationship between higher serum PFAS concentrations and an increased risk of CVD was observed.

Perfluorooctanoic acid exposure is associated with elevated homocysteine and hypertension in US adults

Background exposure to PFOA may continue a risk factor for the development of cardiovascular diseases, as measured by homocysteine level and blood pressure in a representative sample of US adults.

Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities

Adverse associations were not observed between changes in PFOA, PFOS, non-HDL cholesterol, HDL, and hepatic clinical chemistries.

Tenuous dose-response correlations for common disease states: case study of cholesterol and perfluorooctanoate/sulfonate (PFOA/PFOS) in the C8 Health Project

The C8 Health Project and total cholesterol among 46,294 West Virginia residents who lived, worked, or went to school for at least 1 year in a C8 contaminated drinking-water district and were over age 18 in 2005–2006 illustrates the substantial difficulties in assigning toxicological importance to statistical comparisons for common disease states that utilize subgroups with low exposures as an effective control group.



Styrene exposure and ischemic heart disease: a case-cohort study.

Proportional hazards models showed that recent styrene exposure was significantly associated with acute ischemic heart disease death among active workers and the relative hazard of death for exposure during the most recent 2 years was 2.95.

Does arsenic exposure increase the risk for circulatory disease?

Both lagging and adjustment for work status increased circulatory mortality rate ratios at all exposure levels, as compared with a baseline Poisson model, which may indicate that the HWSE obscures an effect of arsenic on circulatory disease.

Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

Mortality among employees of a perfluorooctanoic acid production plant.

  • F. GillilandJ. Mandel
  • Medicine, Biology
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1993
PFOA may increase prostate cancer mortality by altering reproductive hormones in male workers because of its reported role in rodent hepatocarcinogenesis and human health effects associated with PFOA exposure.

Exposure-response models based on extended follow-up of a cohort mortality study in the automobile industry.

Although airborne exposures declined over the study period, this study suggests that modest risk of several digestive cancers, as well as prostatic cancer and leukemia, may persist at current levels of exposure to water-based metalworking fluids.

Does Arsenic Exposure Increase the Risk for Diabetes Mellitus?

The study results show that mortality from DM declined in females (but not in males) gradually after the improvement of drinking water supply system, and the association between arsenic exposure and DM is likely to be casual for females but not in Males.

Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers

The findings indicate a modest positive association of PFOA on some lipid parameters and a need for follow-up studies.

Rectal cancer and exposure to metalworking fluids in the automobile manufacturing industry

Non-parametric smoothing of lagged exposures has shown stronger evidence for a causal association between straight metalworking fluid and rectal cancer than was previously described using standard analytical methods.

An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid.

Results provide reasonable assurance that, in this production setting, there were no significant hormonal changes associated with PFOA at the serum levels measured, compared with those levels reported to cause effects in laboratory animal studies.