Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

  title={Ischaemia–reperfusion injury in liver transplantation—from bench to bedside},
  author={Yuan Zhai and Henrik Petrowsky and Johnny Hong and Ronald W Busuttil and Jerzy W. Kupiec-Weglinski},
  journal={Nature Reviews Gastroenterology &Hepatology},
Ischaemia–reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock, resection and transplantation, is a dynamic process that involves the two interrelated phases of local ischaemic insult and inflammation-mediated reperfusion injury. This Review highlights the latest mechanistic insights into innate–adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia–reperfusion, discusses progress in large… CONTINUE READING
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Publications referenced by this paper.
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Disruption of Type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2012

Past, present and future

Knee Surgery, Sports Traumatology, Arthroscopy • 2012

a pilot study on a novel concept of organ resuscitation in a large animal model

Hong, J. C. et al. Regulated hepatic reperfusion mitigates ischemia, reperfusion injury, improves survival after prolonged liver warm ischemia
J. Am. Coll. Surg. 214, 505–515 • 2012

implications for liver ischemia-reperfusion injury

Chestovich, P. J. et al. Interleukin-22
Transplantation 93, 485–492 • 2012

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