Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

@article{Zhai2013IschaemiareperfusionII,
  title={Ischaemia–reperfusion injury in liver transplantation—from bench to bedside},
  author={Yuan Zhai and Henrik Petrowsky and Johnny Hong and Ronald W Busuttil and Jerzy W. Kupiec-Weglinski},
  journal={Nature Reviews Gastroenterology &Hepatology},
  year={2013},
  volume={10},
  pages={79-89}
}
Ischaemia–reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock, resection and transplantation, is a dynamic process that involves the two interrelated phases of local ischaemic insult and inflammation-mediated reperfusion injury. This Review highlights the latest mechanistic insights into innate–adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia–reperfusion, discusses progress in large… CONTINUE READING
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