Ischaemia–reperfusion injury impairs tissue plasminogen activator release in man

@inproceedings{Pedersen2012IschaemiareperfusionII,
  title={Ischaemia–reperfusion injury impairs tissue plasminogen activator release in man},
  author={Christian Marcus Pedersen and Gareth Barnes and Michael Rahbek Schmidt and Hans Erik B{\o}tker and Rajesh K. Kharbanda and David E. Newby and Nicholas Le May Cruden},
  booktitle={European heart journal},
  year={2012}
}
  • Christian Marcus Pedersen, Gareth Barnes, +4 authors Nicholas Le May Cruden
  • Published in European heart journal 2012
  • Medicine
  • AIMS Ischaemia-reperfusion (IR) injury causes endothelium-dependent vasomotor dysfunction that can be prevented by ischaemic preconditioning. The effects of IR injury and preconditioning on endothelium-dependent tissue plasminogen activator (t-PA) release, an important mediator of endogenous fibrinolysis, remain unknown. METHODS AND RESULTS Ischaemia-reperfusion injury (limb occlusion at 200 mmHg for 20 min) was induced in 22 healthy subjects. In 12 subjects, IR injury was preceded by local… CONTINUE READING

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