Ischaemia‐reperfusion injury

@article{Grace1994IschaemiareperfusionI,
  title={Ischaemia‐reperfusion injury},
  author={Pierce A. Grace},
  journal={British Journal of Surgery},
  year={1994},
  volume={81}
}
  • P. Grace
  • Published 1994
  • Medicine
  • British Journal of Surgery
Ischaemia‐reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production, and the role of neutrophils and endothelial factors in ischaemiareperfusion. Finally, several mechanisms that limit ischaemiareperfusion injury are discussed and a… Expand
Clinical implications of ischaemia-reperfusion injury.
TLDR
An overview of the pathophysiology of IRI is outlined, with direct reference to histological and physiological changes seen in individual organs, and the data on experimental methods of prevention is presented. Expand
Renal ischaemia‐reperfusion injury
TLDR
It appears that relatively less importance should be attached to the involvement of neutrophils at isocheimal‐reperfusion sites, and relatively more to a local postiischaemic imbalance in the levels of nitric oxide and endothelin. Expand
Renal ischaemia--reperfusion injury.
TLDR
It appears that relatively less importance should be attached to the involvement of neutrophils at ischaemia-reperfusion sites, and relatively more to a local postischaemic imbalance in the levels of nitric oxide and endothelin. Expand
The role of the neutrophil in ischaemia-reperfusion injury: potential therapeutic interventions.
TLDR
A review of potential therapeutic interventions that might be employed to minimise ischaemia-reperfusion syndrome and the role of neutrophils is described. Expand
Ischemia reperfusion injury and its therapy: An overview
TLDR
The purpose of this review article is to summarize its pathophysiology, clinical presentation as well as therapeutic strategies to limit ischemia-reperfusion injury. Expand
Ischemia-reperfusion damage.
TLDR
The literature suggests the importance of antioxidant and anti-inflammatory treatment to treat ischemia-reperfusion-related tissue damage. Expand
The Role of the Neutrophil in Ischaemia-Reperfusion Injury: Potential Therapeutic Interventions
The pathogenesis of the reperfusion syndrome is complex and as yet not fully elucidated. It is characterized by the development of increased microvascular permeability, oedema and tissue necrosis,Expand
The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury
As a non-toxic endogenous antioxidant, the semi-essential amino acid taurine is a potential attenuator of oxidative damage such as that produced by ischaemia-reperfusion injury. Ischaemia-reperfusionExpand
Ischemia-Reperfusion in Vascular Surgery
TLDR
A growing body of evidence indicates that the pathogenesis of I-R can be ascribed to the unbalanced oxygen radical generation occurring at reperfusion, when molecular O2 becomes available, known as “oxygen paradox”. Expand
Ischaemia-Reperfusion in Sepsis
TLDR
The concept that it is reperfusion itself that increases and potentiates ischaemia-induced damage has progressively gained ground, and it is now one of the main factors taken into account in the treatment of various pathological states. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 200 REFERENCES
Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
TLDR
Therapeutic options for limiting ischaemia reperfusion injury include inhibition of oxygen radical formation, pharmacological prevention of neutrophil activation and chemotaxis, and also the use of monoclonal antibodies which prevent neutrophIL‐endothelial adhesion, a prerequisite for injury. Expand
Compartment syndromes and reperfusion injury.
  • M. Perry
  • Medicine
  • The Surgical clinics of North America
  • 1988
TLDR
Open compartment syndrome has been defined as increased pressure within a limited space that compromises the blood supply and function of tissues within that space, and if the nerves and muscles can be preserved, the limb will often be relatively normal. Expand
Superoxide, iron, vascular endothelium and reperfusion injury.
  • B. Halliwell
  • Chemistry, Medicine
  • Free radical research communications
  • 1989
TLDR
It is proposed that vascular endothelium has an intrinsic capacity to generate O2- for regulatory purposes such as inactivation of endot Helium-derived relaxing factor, resulting in greater O2 - generation when O2 is restored. Expand
Ischaemic preconditioning
TLDR
The currently favoured hypotheses propose that substances generated as a consequence of preconditioning can modulate the myocardial response to further ischaemia and suggest the possible involvement of one or more of adenosine, nitric oxide,4 prostacyclin,6 and free radicals. Expand
Oxygen-derived free radicals in postischemic tissue injury.
  • J. McCord
  • Medicine
  • The New England journal of medicine
  • 1985
TLDR
It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain. Expand
Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury
It is proposed that vascular endothelium has an intrinsic capacity to generate O2- for regulatory purposes such as inactivation of endothelium-derived relaxing factor. Ischaemia can disrupt theExpand
Mechanisms of postischemic vascular dysfunction in skeletal muscle: implications for therapeutic intervention.
TLDR
The objective of this review is to summarize the supportive evidence for this scheme in postischemic skeletal muscle and to identify the components of the mechanism that may be amenable to pharmacologic intervention. Expand
Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites.
TLDR
The pharmacologic modification of this injury process, with agents that scavenge these reactive oxygen metabolites, block their generation, or enhance the endogenous antioxidant capability, has shown great promise in animal models of common clinical conditions, and has already been successfully applied in controlled clinical trials. Expand
Prevention of postischemic injury in immature intestine by deferoxamine.
TLDR
It is concluded that neonatal bowel ischemia conditions such as necrotizing enterocolitis may be reperfusion injuries wherein free iron plays an important role in tissue injury and administration of an iron chelating agent under such conditions has a beneficial effect on survival and histology. Expand
Hypoxic reperfusion attenuates postischemic microvascular injury.
TLDR
The hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle was tested and solvent drag reflexion coefficient (sigma f) was significantly reduced, indicating a dramatic increase in vascular permeability. Expand
...
1
2
3
4
5
...