Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH.

@article{SchmittHoffmann2016IsavuconazoleAF,
  title={Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH.},
  author={Anne H Schmitt-Hoffmann and Amit Desai and Donna L. Kowalski and Helene Pearlman and Takao Yamazaki and Robert Townsend},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2016},
  volume={54 8},
  pages={572-80}
}
OBJECTIVE/METHODS Two openlabel, single-dose, randomized crossover studies and one open-label, multiple-dose, parallel group study in healthy volunteers were conducted with the prodrug, isavuconazonium sulfate, to determine absolute bioavailability of the active triazole, isavuconazole (EudraCT 2007-004949-15; n = 14), and the effect of food (EudraCT 2007- 004940-63; n = 26), and pH (NCT02128893; n = 24) on the absorption of isavuconazole. Isavuconazonium sulfate 744 mg designed to deliver 400… CONTINUE READING
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