Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study
@article{Attal2019IsatuximabPP, title={Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study}, author={Michel Attal and Paul G. Richardson and S. Vincent Rajkumar and Jesus F F San-Miguel and Meral Beksaç and Ivan {\vS}pi{\vc}ka and Xavier Leleu and F. Schjesvold and Philippe Moreau and Meletios- Athanasios Dimopoulos and Jeffrey Shang-Yi Huang and Jiř{\'i} Minař{\'i}k and Michele Cavo and Henry Miles Prince and Sandrine Mac{\'e} and Kathryn Penkus Corzo and Frank Campana and Solenn Le-Guennec and Franck Dubin and Kenneth C. Anderson and Paul G. Richardson and Vincent S. Rajkumar and Meletios- Athanasios Dimopoulos and Henry Miles Prince and Kathryn Penkus Corzo and Kenneth C. Anderson and Simon James Harrison and Wojt Janowski and Ian Kerridge and Andrew Spencer and Michel Delforge and Karel Fostier and Philip Vlummens and Ka Lung Wu and Richard LeBlanc and Michel Pavic and Michael Sebag and Roman H{\'a}jek and Vladim{\'i}r Maisnar and Ludek Pour and Henrik Gregersen and Lotfi B Benbouker and Denis Caillot and M Escoffre-barbe and Thierry Facon and Laurent Frenzel and Cyrille Hulin and Lionel Karlin and Brigitte Kolb and Brigitte P{\'e}gouri{\'e} and Aurore Perrot and Mourad Tiab and Laure Vincent and Dietger Niederwieser and Achilles Anagnostopoulos and Sosana Delimpasi and Marie-Christine Kyrtsonis and Anargyros Symeonidis and {\'A}rp{\'a}d Ill{\'e}s and G{\'a}bor Mikala and Zsolt Nagy and Sara Bringen and Paolo Corradini and Ciceri Fabio and Roberto M Lemoli and Anna Marina Liberati and Chiara Nozzoli and Renato Zambello and Shinsuke Iida and Takashi Ikeda and Satoshi Iyama and Morio Matsumoto and Chihiro Shimazaki and Kazutaka Sunami and Kenshi Suzuki and Michihiro Uchiyama and Youngil Koh and Kihyun Kim and Jae Hoon Lee and Chang-Ki Min and Hillary Blacklock and Hugh J. B. Goodman and Annette J. Neylon and David Simpson and Sebastian Grosicki and Artur Jurczyszyn and Adam Walter‐Croneck and Krzysztof Warzocha and Lu{\'i}s Ara{\'u}jo and Cl{\'a}udia Moreira and Vadim A Doronin and Larisa P. Mendeleeva and Vladimir Vorobyev and Andrej Vranovsk{\'y} and Adri{\'a}n Alegre and Mercedes Gironella and Marta Sonia Gonz{\'a}lez P{\'e}rez and Carmen Montes and Enrique Mar{\'i}a Ocio and Paula Rodriguez and Mats Hardling and Birgitta Lauri and Ming-chung Wang and Su-Peng Yeh and Mutlu Arat and Fatih Demirkan and Zafer Gulbaş and Sevgi Beşışık and Ihsan Karadoğan and Tulin Firatli Tuglular and Ali Unal and Filiz Vural and Jonathan Sive and Matthew Streetly and Kwee L. Yong and Jason Tache}, journal={The Lancet}, year={2019}, volume={394}, pages={2096-2107} }
306 Citations
Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): follow-up analysis of a randomised, phase 3 study.
- MedicineThe Lancet. Oncology
- 2022
Isatuximab plus pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma according to prior lines of treatment and refractory status: ICARIA-MM subgroup analysis.
- MedicineLeukemia research
- 2021
Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis
- MedicineHaematologica
- 2020
Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis.
Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.
- MedicineThe Lancet. Haematology
- 2022
EMA Review of Isatuximab in Combination with Pomalidomide and Dexamethasone for the Treatment of Adult Patients with Relapsed and Refractory Multiple Myeloma
- Medicine
- 2021
The addition of isatuximab resulted in a clinically meaningful and significant prolongation of the time from treatment initiation to further disease relapse or patient’s death and the safety profile was considered acceptable, and the benefit-risk ratio was determined to be positive.
Addition of isatuximab to lenalidomide, bortezomib, and dexamethasone as induction therapy for newly diagnosed, transplantation-eligible patients with multiple myeloma (GMMG-HD7): part 1 of an open-label, multicentre, randomised, active-controlled, phase 3 trial.
- MedicineThe Lancet. Haematology
- 2022
Pomalidomide, Cyclophosphamide, and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma: Real-World Analysis of the Pethema-GEM Experience.
- MedicineClinical lymphoma, myeloma & leukemia
- 2021
Outcomes of anti-CD38 isatuximab plus pomalidomide and dexamethasone in five relapsed myeloma patients with prior exposure to anti-C38 daratumumab: case series
- MedicineHematology
- 2022
The first UK real-world report of IsaPomDex outcomes in myeloma patients with a prior exposure to daratumumab is described, and large prospective studies are required to further evaluate myel cancer outcomes in this setting.
Isatuximab-Pomalidomide-Dexamethasone Versus Pomalidomide-Dexamethasone in East Asian Patients With Relapsed/Refractory Multiple Myeloma: ICARIA-MM Subgroup Analysis.
- MedicineClinical lymphoma, myeloma & leukemia
- 2022
An evaluation of isatuximab, pomalidomide and dexamethasone for adult patients with relapsed and refractory multiple myeloma
- MedicineExpert review of hematology
- 2021
The current role for isatuximab with pomalidomide for the treatment of relapsed/refractory myeloma (RRMM) is considered and the challenge of where it is best placed in the treatment algorithm remains.
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