Isatin Derivatives as Novel Inhibitors of HIV Integrase/LEDGF Interaction


Series of Novel isatinderivatives were investigated forinhibitionof HIVIntegrase/ Lens epithelium derived growth factor (LEDGF)protein-protein interaction by using ALPHA screen technique. Hypothetical binding modes of the selected compound in HIV integrase were generated using GLIDE docking tool.Isatin derivatives (SP III-5H and SPIII-NA) inhibits HIV IN/LEDGF interaction and SPIII-5H more potent compound (15.1 μM) in this series. Molecular modeling studies indicate that the SPIII-5H can bind within the active site of HIV integrase (DDE) and thus interrupt the binding of HIV integrase with LEDGF.

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@inproceedings{Selvam2013IsatinDA, title={Isatin Derivatives as Novel Inhibitors of HIV Integrase/LEDGF Interaction}, author={Periyasamy Selvam and Nouri Neamati and Tino Sanchenz and Anand Kumar V. Raichurkar and Andra Pradesh}, year={2013} }