Is vitronectin the velcro that binds the gametes together?

@article{Fusi1996IsVT,
  title={Is vitronectin the velcro that binds the gametes together?},
  author={Francesco M. Fusi and N Bernocchi and Augusto Ferrari and Richard Bronson},
  journal={Molecular human reproduction},
  year={1996},
  volume={2 11},
  pages={
          859-66
        }
}
Evidence has been presented that the adhesion of human spermatozoa to the oolemma is mediated by integrins recognizing the Arg-Gly-Asp sequence (RGD). Fibronectin and vitronectin, glycoproteins that contain functional RGD sequences, are both present on human spermatozoa, and integrins that recognize these ligands have been detected on spermatozoa and eggs. In this work, we studied the effects of oligopeptides specifically designed to block fibronectin or vitronectin receptors on the interaction… CONTINUE READING

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