Is vitamin B6 deficiency an under‐recognized risk in patients receiving haemodialysis? A systematic review: 2000–2010

  title={Is vitamin B6 deficiency an under‐recognized risk in patients receiving haemodialysis? A systematic review: 2000–2010},
  author={Melissa Corken and Judi Porter},
Vitamin B6 is a water‐soluble vitamin, important for the normal functioning of multiple organ systems. In patients receiving haemodialysis, vitamin B6 deficiency has been reported. The impact of ongoing advances in renal medicine on vitamin B6 status has not been evaluated. The aims of this review were (i) to determine the current level of vitamin B6 deficiency in the haemodialysis population; (ii) to determine the effect of current haemodialysis prescriptions on vitamin B6 levels; and (iii) to… 

Effect of vitamin and mineral supplementation on nutritional status in children with chronic kidney disease: Protocol for a systematic review and meta-analysis

This review will help better understand the effects of vitamin and mineral supplementation to improve nutritional status in CKD children and will create a guideline to determine the applicability of these interventions in different feasible settings.

Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study

The incidence of various micronutrient deficiencies in critically ill patients who required CRRT was higher than previously reported and potential clinical and metabolic efficacy of supplementation in the intensive care unit setting is needed.

Nutritional Status and Dialysis Modality: Effect on Folate Status 20 Years after the Institution of a National Folic Acid Fortification Program

Current recommendations of high dose supplementation of folic acid and B6 are likely not indicated in ESKD, irrespective of modality.

Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial.

  • Y. ObiS. Mikami Y. Isaka
  • Medicine, Biology
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
  • 2016
Thrice-weekly intravenous vitamin B6 worsens the response to ESA and may blunt the response of bone to parathyroid hormone in hemodialysis patients, which may contribute to anemia and abnormal bone metabolism in this population of patients.

Vitamin and trace element deficiencies in the pediatric dialysis patient

The nutritional sources of key water-soluble vitamins and trace elements are summarized with a focus on the biological roles and clinical manifestations of their respective deficiency to augment awareness of potential nutritional illness in pediatric patients receiving maintenance dialysis.

Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients

Vitamin B-6 status, rather than homocysteine, appeared to be a significant factor in relation to inflammatory responses for CKD and hemodialysis patients.

Erythropoietin-stimulating agent-resistant vitamin B6 deficiency anemia in a pediatric patient on hemodialysis

Vitamin B 6 deficiency anemia should be considered in any pediatric patient on hemodialysis who does not respond to standard ESA and iron therapy.



Guidelines for vitamin supplements in chronic kidney disease patients: what is the evidence?

  • G. HandelmanN. Levin
  • Medicine
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
  • 2011
Because of restricted diets that provide limited vitamin intake from food, many renal patients can benefit from a tablet that adds an amount equal to one recommended daily allowance of water-soluble vitamins, but larger amounts are not appropriate or beneficial.

Vitamin supplementation of patients receiving haemodialysis

It is concluded that supplements of vitamins A and E are not required and, when dietary intakes of water‐soluble vitamins are marginal, these should be supplemented at a dose as near as possible to the recommended dietary intake.

Metabolism of vitamin B6 and its requirement in chronic renal failure.

The daily oral dose of pyridoxine 6 mg was optimal for the patients without erythropoietin (EPO) treatment during the period of 12 months of CAPD and an indirect relationship between the effect of PLP and plasma vitamin B6 was found.

Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin.

  • H. OkadaK. Moriwaki H. Suzuki
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2000
Although vitamin B(6) deficiency could not be demonstrated in patients with chronic renal failure on high-flux HD, vitamin B (6) supplementation was effective in improving PPN symptoms of various aetiologies, possibly because of vitamin B+(6) resistance to PPN in these patients.

Water soluble vitamins in chronic hemodialysis patients and need for supplementation.

The results suggest that in uremia insufficient transketolase activity may be related to inhibition of the enzymatic system rather than to true vitamin deficiency.

Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins.

Nearly 40% of unsupplemented hemodialysis patients were deficient in vitamin B6, and supplementation with DiaVite has resulted in significant tHcy reductions for all three genotypes.

Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency.

Fasting and PML tHcy levels were partially resistant to vitamin B6 supplements, with different response patterns in HD patients and those with CRI, and nonvitamin factors or potentially toxic PA levels may be implicated in abnormal vitamin B 6 and/or tH Cy metabolism during renal insufficiency.

Appropriate Vitamin Therapy for Dialysis Patients

There are several causes of vitamin deficiency in chronic dialysis patients in addition to the removal of water soluble vitamins by the dialysis procedure, including reduced dietary intake, the accumulation of unidentified uremic toxins and the effect of medications upon the absorption or activity of specific vitamins.

Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial.

Among patients with diabetic nephropathy, high doses of B vitamins compared with placebo resulted in a greater decrease in GFR and an increase in vascular events.

Vitamins and quality of life in hemodialysis patients.

Investigations of Investigated vitamins were decreased in hemodialysis patients and after supplementation increased to normal range, andequate supplementation of above mentioned vitamins led to increased quality of life in he modalysis patients from some clinical points of view.