Is vascular depression a distinct sub‐type of depressive disorder? A review of causal evidence

  title={Is vascular depression a distinct sub‐type of depressive disorder? A review of causal evidence},
  author={Robert C. Baldwin},
  journal={International Journal of Geriatric Psychiatry},
  • R. Baldwin
  • Published 1 January 2005
  • Psychology
  • International Journal of Geriatric Psychiatry
Vascular depression is an important conceptual and clinical concept. 
Cerebrovascular risk factors and incident depression in community‐dwelling elderly
Objective:  The ‘vascular depression’ hypothesis suggests that late‐life depression results from vascular brain damage. We studied the longitudinal association between cerebrovascular risk factors
Depression and comorbidity : general practice-based studies on occurence and health care consequences
Depression and comorbidity. General practice-based studies on occurrence and health care consequences.
Hypertension and depression in late life
  • R. Stewart
  • Medicine
    British Journal of Psychiatry
  • 2006
The ‘vascular depression’ hypothesis has attracted considerable interest, but its basis is by no means clear. Kaimal & Nair ([2005][1]) in their recent correspondence mention vascular comorbidity in
Relationship of endothelial function and atherosclerosis to treatment response in late‐life depression
This study investigated the relationship between endothelial function and atherosclerosis and treatment response to antidepressant monotherapy in late‐life depression and found no significant differences between the two.
Cognitive and Communicative Consequences of Cardiovascular Disease
Abstract Purpose: A growing literature has documented that cardiovascular disease (CVD), even prior to causing strokes and other neurological disorders, can negatively affect cognitive and communic...
Pharmacological management of behavioural and psychological disturbance in dementia
A range of drugs commonly used to manage behaviour and psychological symptoms in patients with dementia including antipsychotics, anticonvulsants, antidementia drugs and antidepressants are evaluated.
Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women
This work investigated the temporal relationship between depressive symptoms and WMHs in older men and women and found associations between vascular disease and depression in late life are still unknown.
Depression and anxiety in chronic heart failure and chronic obstructive pulmonary disease: prevalence, relevance, clinical implications and management principles
To review evidence regarding the prevalence, causation, clinical implications, aspects of healthcare utilisation and management of depression and anxiety in chronic heart failure and chronic
Cerebrovascular disease basis of depression: Post-stroke depression and vascular depression
The purpose of this review is to examine the epidemiology, diagnostic features, course, pathophysiology and prognosis of post-stroke depression and vascular depression, to highlight their common features, and to contrast the distinct aspects of these two subtypes of geriatric depression.


Late‐Life Depression is Associated with Arterial Stiffness: A Population‐Based Study
To determine whether arterial stiffness is associated with depression in the elderly, a large number of elderly patients with a history of depression have had arterial stiffening problems.
The prognostic significance of abnormalities seen on magnetic resonance imaging in late life depression: clinical outcome, mortality and progression to dementia at three years
Objective. To study the course of depressive symptoms over 3 years, rate of dementia and mortality in relation to baseline neuroradiological abnormalities.
A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of ‘vascular depression’
Calcium channel blockers are expected to improve depression reduction and to prevent recurrence of depression in this patient population and this clinical trial was designed to test these hypotheses.
Relationship between depression and cerebrovascular disease: conceptual issues.
  • R. Ramasubbu
  • Psychology, Medicine
    Journal of affective disorders
  • 2000
Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depression.
Data did not support the notion that a small-vessel brain disease model of depression might apply to the majority of older persons with depressive symptoms and syndromes in primary-care settings.
'Vascular depression' hypothesis.
We propose that cerebrovascular disease may predispose, precipitate, or perpetuate some geriatric depressive syndromes. The "vascular depression" hypothesis is supported by the comorbidity of
Longitudinal increase in the volume of white matter hyperintensities in late‐onset depression
There is little evidence that a longitudinal increase in WMH burden within an individual is associated with the onset of a late‐life depression, but one finding supporting the increased neuropathology in the form of white matter hyperintensities found in patients diagnosed with a late-onset depression is found.
Depression and vascular disease: what is the relationship?
Age and depression.
Clinical presentation of the "depression-executive dysfunction syndrome" of late life.
Depressive symptomatology, and especially psychomotor retardation and loss of interest in activities, contributed to disability in DED patients, whereas paranoia was associated with disability independently of executive dysfunction.