Is treatment with hydroxyurea leukemogenic in patients with essential thrombocythemia? An analysis of three new cases of leukaemic transformation and review of the literature.

@article{Liozon1997IsTW,
  title={Is treatment with hydroxyurea leukemogenic in patients with essential thrombocythemia? An analysis of three new cases of leukaemic transformation and review of the literature.},
  author={Eric Liozon and Christophe Brigaudeau and Franck Trimoreau and François Desangles and V{\'e}ronique Fermeaux and Vincent Praloran and Dominique Bordessoule},
  journal={Hematology and cell therapy},
  year={1997},
  volume={39 1},
  pages={11-8}
}
From 1981 to 1995, we diagnosed, followed and treated at our institution fifty-eight cases of essential thrombocythemia (ET), using hydroxyurea (HU) as first-line therapy in these patients. Three patients who were continuously receiving HU had a leukemic transformation after a chronic phase of respectively 47, 81 and 90 months. One patient developed an acute leukemia with minimal myeloid differentiation (AML MO) and soon died of refractory disease; the second developed a refractory anemia with… CONTINUE READING
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