Is treatment-associated hypomania rare with duloxetine: secondary analysis of controlled trials in non-bipolar depression.

@article{Dunner2005IsTH,
  title={Is treatment-associated hypomania rare with duloxetine: secondary analysis of controlled trials in non-bipolar depression.},
  author={David L. Dunner and Deborah N D'souza and Daniel K. Kajdasz and Michael J. Detke and James M. Russell},
  journal={Journal of affective disorders},
  year={2005},
  volume={87 1},
  pages={115-9}
}
BACKGROUND Selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs) like duloxetine have the efficacy of tricyclic antidepressants (TCAs) with a more tolerable side-effect profile. Bipolar disorder is often undetected, with the most common misdiagnosis being unipolar depression. Studies have suggested that treatment of bipolar and unipolar depression with heterocyclic TCAs may increase the risk of switch rate to mania. Studies of antidepressants in unipolar major… CONTINUE READING

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