Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?

@article{Li2016IsTS,
  title={Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?},
  author={Nan Li and Dolores D. Mruk and W. M. Peter Lee and Chris K. C. Wong and C Yan Cheng},
  journal={Seminars in cell & developmental biology},
  year={2016},
  volume={59},
  pages={141-156}
}
Sertoli cells isolated from rodents or humans and cultured in vitro are known to establish a functional tight junction (TJ)-permeability barrier that mimics the blood-testis barrier (BTB) in vivo. This model has been widely used by investigators to study the biology of the TJ and the BTB. Studies have shown that environmental toxicants (e.g… CONTINUE READING