Is time to peak effect of neuromuscular blocking agents dependent on dose? Testing the concept of buffered diffusion.

@article{Proost2008IsTT,
  title={Is time to peak effect of neuromuscular blocking agents dependent on dose? Testing the concept of buffered diffusion.},
  author={Johannes H Proost and Martin C. Houwertjes and Jan Mark Klaas Hyltje Wierda},
  journal={European journal of anaesthesiology},
  year={2008},
  volume={25 7},
  pages={572-80}
}
BACKGROUND AND OBJECTIVES For neuromuscular blocking agents, an inverse relationship between potency and time to peak effect has been observed. To test the hypothesis that this relationship is due to buffered diffusion, we investigated the influence of dose on time to peak effect. Pharmacokinetic-pharmacodynamic simulations were performed to support the… CONTINUE READING