Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study.

@article{Krumholz2003IsTE,
  title={Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study.},
  author={Harlan M. Krumholz and Cary P Gross and Eric D. Peterson and Hal V. Barron and Martha J. Radford and Lori S. Parsons and Nathan R. Every},
  journal={American heart journal},
  year={2003},
  volume={146 5},
  pages={839-47}
}
BACKGROUND Some experts have raised concerns about the ability to generalize randomized trials, emphasizing that patients who participate in these studies are often not representative of those seen in clinical practice, particularly in the case of elderly patients. To determine the effect of implicit exclusion criteria on a trial study sample, we compared data from the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO) trial with data from a retrospective… CONTINUE READING

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