Is there circannual variation of human platelet 5-HT(2A) binding in depression?

@article{Khait2002IsTC,
  title={Is there circannual variation of human platelet 5-HT(2A) binding in depression?},
  author={Vadim D Khait and Yung-yu Huang and Kevin M. Malone and Maria A. Oquendo and Beth S. Brodsky and L Sher and J. John Mann},
  journal={Journal of affective disorders},
  year={2002},
  volume={71 1-3},
  pages={249-58}
}
BACKGROUND Seasonal variations in onset of mood disorders and in serotonergic function are reported, but their relationship is unclear. METHODS Circannual variation in platelet 5-HT(2A) binding was measured in 68 healthy subjects and 121 patients with a major depressive episode. In 73 patients the current episode began during Spring or Fall. RESULTS Significant, but different, circannual variations were found in patients compared with controls. Controls had two peaks of B(max), one in… CONTINUE READING