Is there anything really novel on the antidepressant horizon?

  title={Is there anything really novel on the antidepressant horizon?},
  author={James W. Murrough and Dennis S. Charney},
  journal={Current psychiatry reports},
  volume={14 6},
Major depression represents one of the most disabling illnesses worldwide and current treatments are only partially effective. All antidepressant agents modulate the monoamine system, which likely accounts for the similar efficacy profile of available treatments. Herein we summarize the current state of depression therapeutics and assess the antidepressant development pipeline. Antidepressant response rates in controlled trials are estimated at ~54 % and real-world effectiveness data suggests a… CONTINUE READING
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