Is there any relationship between antinociception, doses and plasma levels of clomipramine during subchronic treatment in rats?

@article{Guiol1984IsTA,
  title={Is there any relationship between antinociception, doses and plasma levels of clomipramine during subchronic treatment in rats?},
  author={C Guiol and Michelle A. Tran and Marcel Blanc and J. P. Charlet and Alain Eschalier and J Cotonat and J. L. Montastruc},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={1984},
  volume={38 1},
  pages={59-62}
}
The antinociceptive effects and the plasma levels (evaluated by high liquid pressure chromatography) of clomipramine during a subchronic (5 days) treatment were studied in rats using the Nilsen's test. Clomipramine (10, 20, 30 and 40 mg/kg administered by mouth) showed a clear dose-dependent analgesic effect. The study of the partial correlation… CONTINUE READING