Is there an interchromosomal effect in reciprocal translocation carriers? Sperm FISH studies

@article{Estop2000IsTA,
  title={Is there an interchromosomal effect in reciprocal translocation carriers? Sperm FISH studies},
  author={Anna M. Estop and Kathy M. Cieply and Santiago Munn{\'e} and Urvashi Surti and Anthony N. Wakim and Eleanor Feingold},
  journal={Human Genetics},
  year={2000},
  volume={106},
  pages={517-524}
}
Chromosome translocations have been known to affect disjunction of chromosomes unrelated to the translocation in the mouse and in Drosophila. However, in humans, an interchromosomal effect in chromosome translocations has not been demonstrated. The availability of techniques that allow the study of nondisjunction in sperm cells has permitted us to evaluate the possibility of an interchromosomal effect in male translocation heterozygotes. In this study, multicolor fluorescence in situ… CONTINUE READING