Is there alpha-adrenergic blockade and/or serotonergic blockade during chronic ketanserin treatment?

@article{Ball1985IsTA,
  title={Is there alpha-adrenergic blockade and/or serotonergic blockade during chronic ketanserin treatment?},
  author={Stephen G. Ball and Josephine Robertson},
  journal={Journal of cardiovascular pharmacology},
  year={1985},
  volume={7 Suppl 7},
  pages={
          S120-2
        }
}
Drugs are not absolute in their specificity; the mechanisms by which many agents reduce blood pressure remain disputed. Ketanserin has been shown to have both 5-HT2-serotonergic and alpha 1-adrenergic antagonist activity. Its pharmacological profile makes its designation as a serotonergic antagonist appropriate; however, the relative contributions of at least these two, and perhaps other, mechanisms to the hypotensive effect of ketanserin during long-term oral treatment remain obscure. 
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