Is there a stronger graft-versus-leukemia effect using HLA-haploidentical donors compared with HLA-identical siblings?

@article{Ringdn2016IsTA,
  title={Is there a stronger graft-versus-leukemia effect using HLA-haploidentical donors compared with HLA-identical siblings?},
  author={Olle Ringd{\'e}n and Myriam Labopin and Fabio Ciceri and Andrea Velardi and Andrea Bacigalupo and William Arcese and Ardeshi Ghavamzadeh and Rose Marie Hamladji and Christoph Schmid and Arnon Nagler and Mohamad Mohty},
  journal={Leukemia},
  year={2016},
  volume={30},
  pages={447-455}
}
Haploidentical hematopoietic stem cell transplants (HSCTs) are increasingly used, but it is unknown whether they have a stronger graft-versus-leukemia (GVL) effect. We analyzed 10 679 acute leukemia patients who underwent HSCT from an HLA-matched sibling donor (MSD, n=9815) or a haploidentical donor (⩾2 HLA-antigen disparity, n=864) between 2007 and 2012, reported to the European Group for Blood and Marrow Transplantation. In a Cox regression model, acute and chronic graft-versus-host disease… CONTINUE READING