Is there a role for pyruvate dehydrogenase-phosphatase in the re-activation of hepatic pyruvate dehydrogenase complex after re-feeding?


In starvation, inhibition of the pyruvate dehydrogenase complex (PDH) is associated with activation of PDH kinase secondary to increased fat oxidation through increased mitochondrial acetyl-CoA/CoA and N A D H / N A D + concentration ratios (for review, see Randle, 1986). However, acute inhibition of mitochondria1 fat oxidation by 2-tetradecylglycidate ( T… (More)


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