Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

@article{Welsh2005IsTA,
  title={Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?},
  author={Nils Welsh and Miriam Cnop and Ilham Kharroubi and Marco Bugliani and R. Miguel Lupi and Piero Marchetti and Decio L. Eizirik},
  journal={Diabetes},
  year={2005},
  volume={54 11},
  pages={3238-44}
}
Different degrees of beta-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has been recently suggested that high glucose-induced beta-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1beta (IL-1beta) production by beta-cells, nuclear factor-kappaB (NF-kappaB) activation, and death via Fas-FasL. The aim of this study was to test whether human islet exposure to high glucose in vitro, or to the type 2 diabetes… CONTINUE READING
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