Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?


AIM To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. MATERIALS AND METHODS In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured. The blood samples were analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxy progesterone (17OHP), dehydroepiandrosterone sulfate (DHEAS), antimullerian hormone (AMH), kisspeptin measurements. RESULTS FSH concentration was higher and AMH concentration was lower in DOR group (p < .001, p < .001, respectively). The mean LH, TT and DHEAS levels were higher in PCOS group (p = .001, p < .00 and p = .003, respectively). The 17OHP level did not differ among the groups (p = .15). Women with PCOS possessed the highest kisspeptin level (p = .01). The kisspeptin level was negatively correlated with FSH level (r = -0.18, p = .02) and positively correlated with TT and DHEAS levels (r = 0.17, p = .02 and r = 0.23, p = .003, respectively). CONCLUSIONS Women with PCOS had increased serum kisspeptin levels. Kisspeptin concentrations were negatively correlated with serum FSH and positively correlated with serum TT and DHEAS levels.

DOI: 10.1080/09513590.2017.1379499

Cite this paper

@article{Gorkem2017IsTA, title={Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?}, author={Umit Gorkem and Cihan Togrul and Emine Yılmaz Arslan and Ayla Sargin Oruc and Nuriye Buyukkayaci Duman}, journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology}, year={2017}, pages={1-4} }