Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?

@article{Dantzer2014IsTA,
  title={Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?},
  author={Robert Dantzer and Adam K Walker},
  journal={Journal of Neural Transmission},
  year={2014},
  volume={121},
  pages={925-932}
}
Chronic inflammation in physically ill patients is often associated with the development of symptoms of depression. The mechanisms that are responsible for inflammation-associated depression have been elucidated over the last few years. Kynurenine produced from tryptophan in a reaction catabolized by indoleamine 2,3 dioxygenase is transported into the brain where it is metabolized by microglial enzymes into a number of neurotropic compounds including quinolinic acid, an agonist of N-methyl-d… CONTINUE READING
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