Is there a role for B-cell depletion as therapy for scleroderma? A case report and review of the literature.

@article{Daoussis2010IsTA,
  title={Is there a role for B-cell depletion as therapy for scleroderma? A case report and review of the literature.},
  author={Dimitrios Daoussis and Stamatis-Nick Liossis and Athanassios C. Tsamandas and Christina Kalogeropoulou and Alexandra Kazantzi and Panagiotis G Korfiatis and Georgios Yiannopoulos and Andrew P. Andonopoulos},
  journal={Seminars in arthritis and rheumatism},
  year={2010},
  volume={40 2},
  pages={127-36}
}
OBJECTIVES Rituximab (RTX) has been successfully used in the treatment of several rheumatic diseases with an acceptable safety profile. We present herein a patient with systemic sclerosis (SSc) who exhibited significant improvement of his lung function and skin fibrosis following RTX administration, and review the literature regarding the role of B-cells in SSc and the potential efficacy of RTX in its treatment. METHODS We performed an internet search using the keywords systemic sclerosis… CONTINUE READING

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Rituximab for the long term treatment of severe cutaneous involvement in systemic sclerosis [ abstract ]

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