Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

@article{GozaloMarcilla2018IsTA,
  title={Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)},
  author={Miguel Gozalo-Marcilla and Frank Gasthuys and Stelio Pacca Loureiro Luna and Stijn Schauvliege},
  journal={Journal of Veterinary Pharmacology and Therapeutics},
  year={2018},
  volume={41},
  pages={205–217}
}
The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be… 
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Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion
TLDR
IPC and DEX exert protective effects in experimental small intestinal ischaemia in horses, and IRI further progressed in group C, but not in IPC andDEX.
Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion
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IPC and DEX exert protective effects in experimental small intestinal ischaemia in horses, and IRI further progressed in group C, but not in IPC andDEX.
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References

SHOWING 1-10 OF 49 REFERENCES
Partial intravenous anaesthesia in the horse: a review of intravenous agents used to supplement equine inhalation anaesthesia. Part 1: lidocaine and ketamine.
TLDR
Different drugs and their combinations can be administered systemically in anaesthetized horses, with the aim of reducing the amount of the volatile agent whilst improving the recovery qualities and providing a multimodal analgesic approach.
Balanced Anesthesia in the Equine
TLDR
Cardiovascular function in comparison to lidocaine balance is moderately impaired, but horses show less intraoperative awakening following surgical stimulation, and recovery phase following medetomidine balance is clearly smoother than with any other regimen.
Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies.
TLDR
A dexmedetomidine CRI at the reported dose significantly reduces the minimal alveolar concentration (MAC) of sevoflurane in ponies.
The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2.
TLDR
Fracture repair, out of hours surgery, and age below 1 month was associated with increased risk of dying whereas the use of acepromazine and intravenous anaesthetic agent maintenance of anaesthesia wasassociated with reduced risk.
Partial intravenous anaesthesia in the horse: a review of intravenous agents used to supplement equine inhalation anaesthesia. Part 2: opioids and alpha-2 adrenoceptor agonists.
TLDR
Different drugs and their combinations can be administered systemically in anaesthetized horses aiming to reduce the amount of the volatile agent while improving the recovery qualities and providing a multimodal analgesic approach.
Romifidine as a constant rate infusion in isoflurane anaesthetized horses: a clinical study.
TLDR
No inhalation anaesthetic sparing effect or side effects were observed by using a 40 microg kg (-1) hour(-1) romifidine CRI in isoflurane anaesthetized horses under clinical conditions.
Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies.
TLDR
Dexmedetomidine administration i.v. DEX causes similar cardiopulmonary changes to those caused by other alpha-2 adrenoceptor agonists, but of very short duration, and might be safer for sedation of horses because of its very short-lasting cardiopULmonary side effects.
The pharmacokinetics of dexmedetomidine administered as a constant rate infusion in horses.
TLDR
The level of sedation covaried with the plasma concentration of dexmedetomidine, which implies that for clinical use of DexmedETomidine constant rate infusion in conscious horses, infusion rates can be easily adjusted to effect, and this is preferable to an infusion at a predetermined value.
Clinical comparison of dexmedetomidine and medetomidine for isoflurane balanced anaesthesia in horses.
TLDR
Comparison of the effects of two balanced anaesthetic protocols on sedation, cardiopulmonary function and recovery in horses found that horses administered dexmedetomidine required more than 50% of the medetamidine dose to reach equivalent sedation.
Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses.
TLDR
A dexmedetomidine CRI produced limited cardiopulmonary effects, but significantly improved recovery quality in horses anaesthetized with isoflurane, with recovery scores significantly better in group D.
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