Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

@article{GozaloMarcilla2018IsTA,
  title={Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)},
  author={Miguel Gozalo-Marcilla and Frank Gasthuys and Stelio Pacca Loureiro Luna and Stijn Schauvliege},
  journal={Journal of Veterinary Pharmacology and Therapeutics},
  year={2018},
  volume={41},
  pages={205–217}
}
The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be… 
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14 Citations
Background Citations
3
Methods Citations
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14 Citations

Citation Type

Citation Type

Comparison in Sedative Effects between Dexmedetomidine and Midazolam in Dental Implantation: A Randomized Clinical Trial
TLDR
It is considered that dexmedetomidine can achieve better postoperative analgesia, surgeon satisfaction, and sedation than midazolam.
Different doses of dexmedetomidine in children with non-tracheal intubation intravenous general anesthesia
Objective: To elucidate the clinical efficacy of diverse doses of dexmedetomidine for children who underwent non-tracheal intubation intravenous general anesthesia. Methods: From December 2015 to…
Dexmedetomidine contributes to reduced anesthesia dosages and improves anesthetic effectiveness in the radical resection of gastric cancer
Objective: This study was designed to analyze dexmedetomidine’s effects on and contributions to reduced general anesthesia dosages in anesthesia for the radical resection of gastric cancer. Methods:…
Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature
TLDR
The aim of the present article was to publish the first structured review as a summary of the literature focussing on the recovery phase after general anaesthesia in horses, taking into account the scientific evidence of the individual studies.
Evaluation of the sedative and clinical effects of xylazine, detomidine, medetomidine and dexmedetomidine in miniature donkeys
  • A. Samimi
  • Medicine
    New Zealand veterinary journal
  • 2019
TLDR
Assessment of the sedative and clinical effects of I/V xylazine, detomidine, medetomidine and dexmedETomidine in miniature donkeys found that any of the studied drugs could be used for sedation in healthy miniatureDonkeys.
Plasma concentrations at two dexmedetomidine constant rate infusions in isoflurane anaesthetized horses: a clinical study.
TLDR
Infusion of dexmedetomidine in isoflurane anaesthetized horses resulted in plasma concentrations with low variation at both infusion rates, approaching stable levels after 75 minutes of infusion.
Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists
TLDR
Semen collection by urethral catheterization after using α2-adrenergic agonists is a recently developed technique in feline species that is considered to be quick and highly applicable to assisted reproduction programs in felids.
Clinical Randomized Comparison of Medetomidine and Xylazine for Isoflurane Balanced Anesthesia in Horses
TLDR
In horses anesthetized with isoflurane and medetomidine or Xylazine, xylazine maintained higher MAP, reduced the dobutamine consumption and recovery time, whilst overall recovery quality was unaffected.
Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion
TLDR
IPC and DEX exert protective effects in experimental small intestinal ischaemia in horses, and IRI further progressed in group C, but not in IPC andDEX.
Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion
TLDR
IPC and DEX exert protective effects in experimental small intestinal ischaemia in horses, and IRI further progressed in group C, but not in IPC andDEX.
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References

SHOWING 1-10 OF 49 REFERENCES
Partial intravenous anaesthesia in the horse: a review of intravenous agents used to supplement equine inhalation anaesthesia. Part 1: lidocaine and ketamine.
TLDR
Different drugs and their combinations can be administered systemically in anaesthetized horses, with the aim of reducing the amount of the volatile agent whilst improving the recovery qualities and providing a multimodal analgesic approach.
Balanced Anesthesia in the Equine
TLDR
Cardiovascular function in comparison to lidocaine balance is moderately impaired, but horses show less intraoperative awakening following surgical stimulation, and recovery phase following medetomidine balance is clearly smoother than with any other regimen.
Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies.
TLDR
A dexmedetomidine CRI at the reported dose significantly reduces the minimal alveolar concentration (MAC) of sevoflurane in ponies.
The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2.
TLDR
Fracture repair, out of hours surgery, and age below 1 month was associated with increased risk of dying whereas the use of acepromazine and intravenous anaesthetic agent maintenance of anaesthesia wasassociated with reduced risk.
Partial intravenous anaesthesia in the horse: a review of intravenous agents used to supplement equine inhalation anaesthesia. Part 2: opioids and alpha-2 adrenoceptor agonists.
TLDR
Different drugs and their combinations can be administered systemically in anaesthetized horses aiming to reduce the amount of the volatile agent while improving the recovery qualities and providing a multimodal analgesic approach.
Romifidine as a constant rate infusion in isoflurane anaesthetized horses: a clinical study.
TLDR
No inhalation anaesthetic sparing effect or side effects were observed by using a 40 microg kg (-1) hour(-1) romifidine CRI in isoflurane anaesthetized horses under clinical conditions.
Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies.
TLDR
Dexmedetomidine administration i.v. DEX causes similar cardiopulmonary changes to those caused by other alpha-2 adrenoceptor agonists, but of very short duration, and might be safer for sedation of horses because of its very short-lasting cardiopULmonary side effects.
The pharmacokinetics of dexmedetomidine administered as a constant rate infusion in horses.
TLDR
The level of sedation covaried with the plasma concentration of dexmedetomidine, which implies that for clinical use of DexmedETomidine constant rate infusion in conscious horses, infusion rates can be easily adjusted to effect, and this is preferable to an infusion at a predetermined value.
Clinical comparison of dexmedetomidine and medetomidine for isoflurane balanced anaesthesia in horses.
TLDR
Comparison of the effects of two balanced anaesthetic protocols on sedation, cardiopulmonary function and recovery in horses found that horses administered dexmedetomidine required more than 50% of the medetamidine dose to reach equivalent sedation.
Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses.
TLDR
A dexmedetomidine CRI produced limited cardiopulmonary effects, but significantly improved recovery quality in horses anaesthetized with isoflurane, with recovery scores significantly better in group D.
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