Is there a pharmacological basis for differences in 5-HT3-receptor antagonist efficacy in refractory patients?

  title={Is there a pharmacological basis for differences in 5-HT3-receptor antagonist efficacy in refractory patients?},
  author={R. de Wit and M. Aapro and P. Blower},
  journal={Cancer Chemotherapy and Pharmacology},
  • R. de Wit, M. Aapro, P. Blower
  • Published 2005
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • Abstract5-HT3-receptor antagonists are the current antiemetic ‘gold standard’ for chemotherapy- and radiotherapy-induced nausea and vomiting. Interestingly, studies have shown that patients experiencing poor control of acute chemotherapy-induced nausea and vomiting with one antiemetic therapy may respond well to another agent, including a drug of the same class. This review examines pharmacological differences between the 5-HT3-receptor antagonists in order to determine potential reasons for… CONTINUE READING
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