Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection?

@article{Papatheodoridis2008IsTA,
  title={Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection?},
  author={G V Papatheodoridis and Emanuel K Manesis and Spilios G Manolakopoulos and Ioannis S. Elefsiniotis and John Goulis and John Giannousis and Antonios Bilalis and Georgia Kafiri and Dimitrios Tzourmakliotis and Athanasios J. Archimandritis},
  journal={Hepatology},
  year={2008},
  volume={48 5},
  pages={1451-9}
}
UNLABELLED The diagnosis of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B indicating therapeutic intervention currently requires serum hepatitis B virus (HBV) DNA >or=2,000 IU/mL. We evaluated the severity of liver histology and the presence of histological indication for treatment in patients with HBeAg-negative chronic HBV infection focusing on those with low viremia and/or normal alanine aminotransferase (ALT). In total, 399 patients with increased ALT and detectable serum HBV… CONTINUE READING

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Chronic hepatitis B. HEPATOLOGY 2007;45:507539

  • Lok ASF, BJ McMahon
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